Why obesity decrease number & sensitivity of Insulin receptors ?

Question

i mean why free fatty acids increase insulin resistance ???

Answer 1

Obesity is presently defined by body mass index - which is your weight in kilograms divided by your height in meters squared. If you type body mass index into any search engine you will find multiple sites which will calculate your BMI is you input your height and weight. In 1998 the National Institutes of Health in the US came up with a correlation between BMI and future cardiovascular risk (heart attacks and strokes). Bear in mind that these definitions were based upon those age 25 and older and only for those caucasians of European descent. If you are black, Latino, or Asian these numbers will not be correct for you. In addition if you are under age 25 we lack consensus guidelines on how to determine the validity of the BMI. A BMI of less than 18.5 kg/M2 is not healthy rather the goal is a BMI of 18.5 to 25. Between 25 and 30 is considered 'overweight' and only a slight increase in cardiovascular risk. 30 to 35 is level 1 obesity, 35 to 40 is level 2 obesity, and above 40 is level 3 or morbid obesity. At this point we regard anyone with a BMI above 40 to have a genetic disorder (meaning it is not that you are eating too much) and gastric laparoscopic banding is the recommendation. Lap banding is also recommended for those with a BMI between 35 and 40 with a co-morbid condition such as hypertension or diabetes. We do not know why increasing weight leads to insulin resistance. This is most important in skeletal muscle cells as they are the primary users of glucose. It is true that elevated insulin levels and / or elevated glucose levels will affect the number and sensitivity of insulin receptors. Bear in mind that there may be 10s of thousands of insulin receptors of a cell's surface. There is also a paradox. As the 'density' (number) of insulin receptors decrease the sensitivity of the remaining receptors increases. This would imply that although there are fewer receptors that these receptors are more efficient and that the glucose level should not change. I am certain that you already know that this is not the case and that insulin resistance leads to an increase in blood glucose and is a risk factor for the development of type 2 diabetes. The answer to why this paradox 'does not work' is that we do not know what happens to the glucose once it enters the cell. For 25 years we have been searching for what is referred to as a 'second' messenger - something that would explain what happens to the glucose when it enters a cell with insulin resistance. Alas - we are no closer to understanding this than 25 years ago when a second messenger was proposed. Free fatty acids (triglycerides) do not increase insulin resistance. Quite the opposite is true. Insulin resistance and elevations in glucose trigger the liver to release more triglycerides when the liver should be retaining triglycerides. Again - the relationship between BMI, insulin resistance, and elevations in glucose (or glucose intolerance) are know to increase triglycerides we do not understand the mechanism. If the insulin resistance or the glucose level is reduced then the triglycerides will decrease as well. If you have additional questions please email me at [e-mail]. I wish you the very best of health and may God Bless.

Answer 2

Obesity and diabetes go hand in hand. I've hear of cases where a person gained 30+ pounds and cannot use insulin any more because of it.

Answer 3

I have the identical situation and that is what my medical professionals (at house and in England) advised me: restrict white bread and all wheat flour merchandise cut back on sugar up to viable restrict ingesting fruit juice recreation consume three foods an afternoon, mainly breakfast to hold sugar stages down Good success!